Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1995-9-11
pubmed:abstractText
The HS1 protein is one of the major substrates of non-receptor-type protein-tyrosine kinases and is phosphorylated immediately after crosslinking of the surface IgM on B cells. The mouse B-lymphoma cell line WEHI-231 is known to undergo apoptosis upon crosslinking of surface IgM by anti-IgM antibodies. Variants of WEHI-231 that were resistant to anti-IgM-induced apoptosis expressed dramatically reduced levels of HS1 protein. Expression of the human HS1 protein from an expression vector introduced into one of the variant cell lines restored the sensitivity of the cells to apoptosis induced by surface IgM crosslinking. These results suggest that HS1 protein plays a crucial role in the B-cell antigen receptor-mediated signal transduction pathway that leads to apoptosis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1333943, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1371009, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1375396, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1394438, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1396582, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1569106, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1574128, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1578127, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1702903, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1708916, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1714601, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1900155, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-1944535, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2011584, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2138816, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2209683, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2217205, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2369921, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2501658, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2507924, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2587259, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2668012, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2783762, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-2994046, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-3050531, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-3126226, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-3413107, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-6206500, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-6330566, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-6399977, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-7511643, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-7513431, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-7519995, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-7680959, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-7682714, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-7690139, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8088319, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8197455, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8223858, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8293461, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8349298, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8419471, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8431943, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8438166, http://linkedlifedata.com/resource/pubmed/commentcorrection/7638185-8467805
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7302-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate.
pubmed:affiliation
Department of Molecular Immunology, Kyushu University, Fukuoka, Japan.
pubmed:publicationType
Journal Article
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