| pubmed-article:7638173 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7638173 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7638173 | lifeskim:mentions | umls-concept:C1335858 | lld:lifeskim |
| pubmed-article:7638173 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7638173 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:7638173 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:7638173 | lifeskim:mentions | umls-concept:C0002270 | lld:lifeskim |
| pubmed-article:7638173 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:7638173 | pubmed:dateCreated | 1995-9-11 | lld:pubmed |
| pubmed-article:7638173 | pubmed:abstractText | The 5' flanking region of the human alpha-globin gene is highly G + C rich and contains multiple copies of the consensus sequence for the Sp1 binding site. We investigated the role of this G + C-rich region in augmenting alpha-globin promoter activity in the presence of the far-upstream alpha-globin enhancer, HS-40. We show that in transiently transfected erythroid cells, deletion of the alpha-globin G + C-rich 5' flanking region has no effect on alpha-globin promoter activity. However, upon stable integration into chromatin, deletion of this region causes a nearly 90% decrease in promoter activity compared with expression from an alpha-globin promoter retaining this region. These results suggest that the alpha-globin G + C-rich 5' flanking region augments alpha-globin promoter activity in a chromatin-dependent manner. We further show that this G + C-rich region is required for the activation of alpha-globin gene expression during erythroid differentiation. Finally, we show by both footprint analysis and functional assays that the ability of the G + C-rich region to increase alpha-globin promoter activity from a stably integrated alpha-globin gene is mediated by its multiple binding sites for the transcription factor Sp1. | lld:pubmed |
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| pubmed-article:7638173 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7638173 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7638173 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7638173 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7638173 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7638173 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7638173 | pubmed:author | pubmed-author:MurphySS | lld:pubmed |
| pubmed-article:7638173 | pubmed:author | pubmed-author:ProudfootN... | lld:pubmed |
| pubmed-article:7638173 | pubmed:author | pubmed-author:PearsonLL | lld:pubmed |
| pubmed-article:7638173 | pubmed:author | pubmed-author:PondelM DMD | lld:pubmed |
| pubmed-article:7638173 | pubmed:author | pubmed-author:CraddockCC | lld:pubmed |
| pubmed-article:7638173 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7638173 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7638173 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7638173 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7638173 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7638173 | pubmed:pagination | 7237-41 | lld:pubmed |
| pubmed-article:7638173 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7638173 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7638173 | pubmed:articleTitle | Sp1 functions in a chromatin-dependent manner to augment human alpha-globin promoter activity. | lld:pubmed |
| pubmed-article:7638173 | pubmed:affiliation | Sir William Dunn School of Pathology, Chemical Pathology Unit, Oxford University, United Kingdom. | lld:pubmed |
| pubmed-article:7638173 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7638173 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7638173 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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