Linked Life Data

7637480

Source:http://linkedlifedata.com/resource/pubmed/id/7637480

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8973
pubmed:dateCreated
1995-9-14
pubmed:abstractText
To study whether vascular dysfunction in hypercholesterolaemia is reversible, we investigated patients without overt arterial disease who were taking maintenance treatment for hypercholesterolaemia. Medication was stopped for 2 weeks, reinstituted for 12 weeks, and again stopped for 6 weeks. During both maintenance treatment and the 12 weeks of step-up medication the lipid profile was improved but did not return to normal. Dose-response curves for serotonin-induced vasodilatation, an index of nitric oxide-dependent vasodilatation, showed a comparable and significant rightward shift after a medication-free period of 2 and 6 weeks compared with control subjects, indicating endothelial dysfunction, which was already maximum after 2 weeks. After 12 weeks of lipid-lowering medication, the difference in endothelial function between controls and patients had disappeared. Co-infusion of L-arginine, the substrate for nitric oxide synthase, returned the impaired serotonin response during hypercholesterolaemia to normal, but had no effect on this response in controls or in patients while on lipid-lowering medication. Neither endothelium-independent vasorelaxation, assessed by sodium nitroprusside infusion, nor vasoconstriction induced by the nitric oxide blocker L-NMMA, were different between controls and patients, whether the latter were on or off lipid-lowering medication. Our results show an L-arginine-sensitive, impaired nitric-oxide-mediated vascular relaxation of forearm resistance vessels in hypercholesterolaemia which is reproducible, and reversible after short-term lipid-lowering therapy. Demonstration of such changes in this readily accessible vascular bed will allow larger trials assessing vascular function during lipid-lowering therapy to be done.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
346
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
467-71
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:7637480-Adult, pubmed-meshheading:7637480-Arginine, pubmed-meshheading:7637480-Blood Pressure, pubmed-meshheading:7637480-Cholesterol, pubmed-meshheading:7637480-Cholestyramine Resin, pubmed-meshheading:7637480-Dose-Response Relationship, Drug, pubmed-meshheading:7637480-Drug Therapy, Combination, pubmed-meshheading:7637480-Female, pubmed-meshheading:7637480-Forearm, pubmed-meshheading:7637480-Humans, pubmed-meshheading:7637480-Hyperlipoproteinemia Type II, pubmed-meshheading:7637480-Hypolipidemic Agents, pubmed-meshheading:7637480-Infusions, Intravenous, pubmed-meshheading:7637480-Lovastatin, pubmed-meshheading:7637480-Male, pubmed-meshheading:7637480-Nitroprusside, pubmed-meshheading:7637480-Regional Blood Flow, pubmed-meshheading:7637480-Serotonin, pubmed-meshheading:7637480-Simvastatin, pubmed-meshheading:7637480-Vasodilation, pubmed-meshheading:7637480-omega-N-Methylarginine
pubmed:year
1995
pubmed:articleTitle
Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication.
pubmed:affiliation
Department of Nephrology, University Hospital Utrecht, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't