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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1995-9-14
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pubmed:abstractText |
Hepatitis C virus (HCV) is a major causative agent of parenterally transmitted non-A, non-B hepatitis. The genomic region encoding the virion-associated core protein is relatively conserved among HCV strains. To generate a DNA vaccine capable of expressing the HCV core protein, the genomic region encoding amino acid residues 1 to 191 of the HCV-1 strain was amplified and cloned into an eukaryotic expression vector. Intramuscular inoculation of recombinant plasmid DNA into BALB/c mice (H-2d) generated core-specific antibody responses, lymphoproliferative responses, and cytotoxic T-lymphocyte activity. Our results suggest that the HCV core polynucleotide warrants further investigation as a potential vaccine against HCV infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-1385523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-1648221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-1650328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-1690918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-2509915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-2523562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-2999259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7512163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7519785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7533115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7691940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7692197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7693974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-7937907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8116236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8146130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8207814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8212843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8265577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8350420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8456293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8456302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8483929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637033-8510226
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5859-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7637033-3T3 Cells,
pubmed-meshheading:7637033-Amino Acid Sequence,
pubmed-meshheading:7637033-Animals,
pubmed-meshheading:7637033-Antibody Formation,
pubmed-meshheading:7637033-Base Sequence,
pubmed-meshheading:7637033-Cloning, Molecular,
pubmed-meshheading:7637033-DNA, Viral,
pubmed-meshheading:7637033-DNA Primers,
pubmed-meshheading:7637033-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7637033-Female,
pubmed-meshheading:7637033-Hepacivirus,
pubmed-meshheading:7637033-Lymphocyte Activation,
pubmed-meshheading:7637033-Mice,
pubmed-meshheading:7637033-Mice, Inbred BALB C,
pubmed-meshheading:7637033-Molecular Sequence Data,
pubmed-meshheading:7637033-Peptide Fragments,
pubmed-meshheading:7637033-Plasmids,
pubmed-meshheading:7637033-Polymerase Chain Reaction,
pubmed-meshheading:7637033-Recombinant Proteins,
pubmed-meshheading:7637033-Transfection,
pubmed-meshheading:7637033-Vaccines, Synthetic,
pubmed-meshheading:7637033-Viral Core Proteins,
pubmed-meshheading:7637033-Viral Vaccines
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pubmed:year |
1995
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pubmed:articleTitle |
Immune responses to plasmid DNA encoding the hepatitis C virus core protein.
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pubmed:affiliation |
Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, MO 63104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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