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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1995-9-14
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pubmed:abstractText |
Binding of foot-and-mouth disease virus (FMDV) to cells requires an arginine-glycine-aspartic acid (RGD) sequence in the capsid protein VP1. We have genetically engineered an FMDV in which these three amino acids have been deleted, producing a virus particle which is unable to bind to cells. Cattle vaccinated with these receptor binding site-deleted virions were protected from disease when challenged with a virulent virus, demonstrating that these RGD-deleted viruses could serve as the basis for foot-and-mouth disease vaccines safer than those currently in use. This strategy may prove useful in the development of vaccines for other viral diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-14125897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-167679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-1699132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-2163574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-2168107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-2467993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-2537470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-2543752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-3033288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-4286222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-4301615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-6205165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-7523697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-7691985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-8127909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-8385272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7637023-8394441
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5787-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7637023-Amino Acid Sequence,
pubmed-meshheading:7637023-Animals,
pubmed-meshheading:7637023-Aphthovirus,
pubmed-meshheading:7637023-Binding Sites,
pubmed-meshheading:7637023-Cattle,
pubmed-meshheading:7637023-Foot-and-Mouth Disease,
pubmed-meshheading:7637023-Molecular Sequence Data,
pubmed-meshheading:7637023-Oligopeptides,
pubmed-meshheading:7637023-Receptors, Virus,
pubmed-meshheading:7637023-Sequence Deletion,
pubmed-meshheading:7637023-Vaccines, Inactivated,
pubmed-meshheading:7637023-Viral Vaccines,
pubmed-meshheading:7637023-Virion
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pubmed:year |
1995
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pubmed:articleTitle |
Receptor binding site-deleted foot-and-mouth disease (FMD) virus protects cattle from FMD.
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pubmed:affiliation |
Plum Island Animal Disease Center, U.S. Department of Agriculture, Greenport, New York 11944, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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