Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1995-9-14
pubmed:abstractText
The Rel/NF-kappa B family of transcription factors participates in the regulation of genes involved in defense responses, inflammation, healing and regeneration processes, and embryogenesis. The control of the transcriptional activation potential of the Rel/NF-kappa B proteins is mediated, in part, by their association with inhibitory proteins of the I kappa B family. This association results in the cytoplasmic retention of these factors until the cell receives a proper stimulatory signal. The I kappa B alpha gene is a target for regulation by the Rel/NF-kappa B proteins and is in fact upregulated in response to Rel/NF-kappa B activation. A naturally occurring oncogenic variant of the Rel/NF-kappa B family, v-rel, transforms avian lymphocytes, bone marrow cells, monocytes, and fibroblasts. Avian I kappa B alpha expression is upregulated in cells transformed by v-Rel. Avian I kappa B alpha is also upregulated in fibroblasts overexpressing c-Rel and oncogenic variants of c-Rel. c-Rel, a carboxy-terminally truncated variant of c-Rel, and v-Rel are all able to directly transactivate the expression of the avian I kappa B alpha gene. However, c-Rel was the most potent activator of this gene, and the induction of I kappa B alpha expression showed faster kinetics in cells overexpressing c-Rel than in those overexpressing v-Rel. The regulation of I kappa B alpha induction by the Rel proteins was shown to be dependent on a 362-bp region of the I kappa B alpha promoter that contains two potential NF-kappa B binding sites and one AP-1-like binding site. Results of electrophoretic mobility shift assays using these NF-kappa B binding sites indicate that major changes in the profile of DNA binding complexes in fibroblasts overexpressing v-Rel correlated temporally with the kinetic changes in v-Rel's ability to activate the expression of the I kappa B alpha gene.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1327144, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1330326, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1423619, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1425595, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1493333, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1533881, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1533932, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1547506, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1604322, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1656369, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1675604, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1740105, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1741161, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1781029, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1891714, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1903456, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-1907941, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2006423, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2018779, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2153225, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2179815, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2203531, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2203533, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2225078, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2543940, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2598266, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2771659, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2828665, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-2829425, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-3004745, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-6090694, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-6275117, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-6312449, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7679069, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7692236, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7745683, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7933095, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7935382, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7937093, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7957109, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-7983736, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8096091, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8138992, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8175790, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8196632, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8208540, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8230480, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8262046, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8278379, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8319912, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8321203, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8355682, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8404856, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8413269, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8416374, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8438564, http://linkedlifedata.com/resource/pubmed/commentcorrection/7636983-8453667
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Luciferases, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins v-rel, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-rel, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Retroviridae Proteins, Oncogenic, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:geneSymbol
v-rel
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5383-90
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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