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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1995-9-12
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pubmed:abstractText |
The synthesis and sigma 1 and sigma 2 binding properties of several 1'- and 3'-halo- and 1',3'-dihalo-substituted analogues of (+)-N-benzyl- and (+)- and (-)-N-dimethylallyl-N-normetazocine are presented. Structure-activity relationship analyses of the binding data showed that halogen substitution at the 1'-position of these N-substituted N-normetazocine analogues had little effect on sigma 1 binding affinity, whereas 3'-halo substitution as well as 1',3'-dihalo substitution resulted in a reduction of affinity. sigma 2 affinity was increased by the presence of a 3'-bromo substituent in this series of (+)-N-substituted N-normetazocines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2986-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7636861-Animals,
pubmed-meshheading:7636861-Cyclazocine,
pubmed-meshheading:7636861-Guinea Pigs,
pubmed-meshheading:7636861-Hydrocarbons, Halogenated,
pubmed-meshheading:7636861-Narcotics,
pubmed-meshheading:7636861-Pentazocine,
pubmed-meshheading:7636861-Rats,
pubmed-meshheading:7636861-Receptors, sigma,
pubmed-meshheading:7636861-Structure-Activity Relationship
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pubmed:year |
1995
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pubmed:articleTitle |
Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues.
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pubmed:affiliation |
Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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