Linked Life Data

7635973

Source:http://linkedlifedata.com/resource/pubmed/id/7635973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-9-11
pubmed:abstractText
Whether insulin-mediated vasodilation is important in determining insulin's overall action to stimulate glucose uptake is unknown. To this end, we measured leg glucose uptake during euglycemic hyperinsulinemic clamps performed at two insulin doses (40 mU/m2 per min, n = 6 and 120 mU/m2 per min, n = 15) alone and during a superimposed intrafemoral artery infusion of GN-monomethyl-L-arginine (L-NMMA) designed to blunt insulin-mediated vasodilation. During the higher dose study, hyperinsulinemia resulted in about a twofold rise in basal leg blood flow from 0.24 +/- 0.02 to 0.45 +/- 0.05 liter/min, P < 0.0001. L-NMMA infusion resulted in a net 21% reduction in leg glucose uptake from 114 +/- 18 mg/min to 85 +/- 13 mg/min, P < 0.001. We also found a significant relationship between the rate of insulin-stimulated whole body glucose uptake and the magnitude of flow dependent glucose uptake (r = 0.57, P = 0.02). Data obtained during the lower dose insulin infusion resulted in similar findings. In conclusion, in healthy lean subjects, insulin-stimulated muscle blood flow contributes to both insulin responsiveness and insulin sensitivity. The most insulin-sensitive subjects appear to be the most reliant on muscle perfusion for insulin action. Insulin-mediated vasodilation is an important physiological determinant of insulin action.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-1499861, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-1590453, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-16695873, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-2010535, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-2040704, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-2189893, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-3059816, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-8074198, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-8141283, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-8282776, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-8349811, http://linkedlifedata.com/resource/pubmed/commentcorrection/7635973-8428775
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
786-92
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans.
pubmed:affiliation
Department of Medicine, Indiana University Medical Center, Indianapolis 46202, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't