| pubmed-article:7635308 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7635308 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:7635308 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:7635308 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:7635308 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7635308 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:7635308 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7635308 | pubmed:dateCreated | 1995-9-13 | lld:pubmed |
| pubmed-article:7635308 | pubmed:abstractText | Double-strand DNA breaks (DSBs) initiate meiotic recombination in Saccharomyces cerevisiae. DSBs occur at sites that are hypersensitive in nuclease digests of chromatin, suggesting a role for chromatin structure in determining DSB location. We show here that the frequency of DSBs at a site is not determined simply by DNA sequence or by features of chromatin structure. An arg4-containing plasmid was inserted at several different locations in the yeast genome. Meiosis-induced DSBs occurred at similar sites in pBR322-derived portions of the construct at all insert loci, and the frequency of these breaks varied in a manner that mirrored the frequency of meiotic recombination in the arg4 portion of the insert. However, DSBs did not occur in the insert-borne arg4 gene at a site that is frequently broken at the normal ARG4 locus, even though the insert-borne arg4 gene and the normal ARG4 locus displayed similar DNase I hypersensitivity patterns. Deletions that removed active DSB sites from an insert at HIS4 restored breaks to the insert-borne arg4 gene and to a DSB site in flanking chromosomal sequences. We conclude that the frequency of DSB at a site can be affected by sequences several thousand nucleotides away and suggest that this is because of competition between DSB sites for locally limited factors. | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7635308 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635308 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7635308 | pubmed:month | May | lld:pubmed |
| pubmed-article:7635308 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:7635308 | pubmed:author | pubmed-author:LichterII | lld:pubmed |
| pubmed-article:7635308 | pubmed:author | pubmed-author:WuT CTC | lld:pubmed |
| pubmed-article:7635308 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7635308 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:7635308 | pubmed:geneSymbol | HIS4 | lld:pubmed |
| pubmed-article:7635308 | pubmed:geneSymbol | LEU2 | lld:pubmed |
| pubmed-article:7635308 | pubmed:geneSymbol | ARG4 | lld:pubmed |
| pubmed-article:7635308 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7635308 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7635308 | pubmed:pagination | 55-66 | lld:pubmed |
| pubmed-article:7635308 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:meshHeading | pubmed-meshheading:7635308-... | lld:pubmed |
| pubmed-article:7635308 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7635308 | pubmed:articleTitle | Factors that affect the location and frequency of meiosis-induced double-strand breaks in Saccharomyces cerevisiae. | lld:pubmed |
| pubmed-article:7635308 | pubmed:affiliation | Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:7635308 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7635308 | lld:pubmed |
