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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1995-9-14
|
| pubmed:abstractText |
We describe baseline characteristics, enrollment, progression and mortality of the Edinburgh City Hospital HIV cohort. There were 431 men and 191 (31%) women; 439 (71%) infected via injection drug use (IDU); 92 (15%) via homosexual intercourse; 84 (13%) via heterosexual intercourse and 7 from blood products. Median annual rate of CD4 cell loss was 49 (90% range: 15-146); Both homosexual men and patients aged > 40 years at enrollment lost CD4 cells significantly more quickly. In multifactorial analysis controlled for baseline CD4 count and IgA, there was no gender effect, but young patients (< 25 years) progressed significantly more slowly to AIDS (RR 0.4, p = 0.00). Homosexual men progressed significantly more quickly than IDUs, with adjusted relative risks (RR) of 2.9 (p = 0.00), 2.5 (p = 0.01) and 1.5 (p = 0.1) for progression to CDC stage IV, AIDS and death, respectively. The three-year survival rate post-AIDS was 25% (SE 4.3) and there was no gender effect on survival. There was, however, an age effect whereby individuals diagnosed with AIDS in their 40s or later showed poorer survival (RR 1.9, p = 0.04). Zidovudine treatment after an AIDS diagnosis significantly lengthened post-AIDS survival (RR 0.5, p = 0.08).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1460-2725
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
479-91
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7633874-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7633874-Adult,
pubmed-meshheading:7633874-CD4 Lymphocyte Count,
pubmed-meshheading:7633874-Cohort Studies,
pubmed-meshheading:7633874-Disease Progression,
pubmed-meshheading:7633874-Female,
pubmed-meshheading:7633874-HIV Infections,
pubmed-meshheading:7633874-Humans,
pubmed-meshheading:7633874-Male,
pubmed-meshheading:7633874-Prognosis,
pubmed-meshheading:7633874-Scotland,
pubmed-meshheading:7633874-Survival Rate
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
The Edinburgh City Hospital cohort: analysis of enrollment, progression and mortality by baseline covariates.
|
| pubmed:affiliation |
Regional Infectious Disease Unit, City Hospital, Edinburgh.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|