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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-9-14
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pubmed:abstractText |
The purpose of this study was to determine if the measurement of surfactant protein A (SP-A) in bronchoalveolar lavage (BAL) fluid predicts survival in patients with idiopathic pulmonary fibrosis (IPF). We performed BAL on 44 patients with IPF and 33 healthy volunteers. SP-A and total phospholipid (PL) were measured in the surfactant pelleted by centrifugation and expressed as a ratio to account for differences in the alveolar surface area sampled. The mean SP-A/PL was lower in patients with IPF than in healthy volunteers (31.8 +/- 2.8 versus 63.9 +/- 6.4 micrograms/mumol, p = 0.006) and in patients who died within 2 yr than in those who survived (23.4 +/- 2.6 versus 37.5 +/- 4.2 micrograms/mumol, p = 0.015). Using Cox's proportional hazard model, we found that SP-A/PL modeled continuously was associated with survival time (p = 0.002). The 5-yr survival of patients with SP-A/PL above the median level for all patients with IPF (29.7 micrograms/mumol) was more than twice that of patients below the median (68 versus 30%, p = 0.007). SP-A/PL improved upon prediction of survival modeled by most routine physiologic variables with the exception of percent predicted TLC or the multifarious clinical-radiographic-physiologic score (CRP). Cellular analysis of lavage did not predict survival in this cohort of patients. We conclude that SP-A/PL is a biochemical marker in lavage that predicts survival in patients with IPF.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1073-449X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
751-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7633738-Adult,
pubmed-meshheading:7633738-Aged,
pubmed-meshheading:7633738-Biological Markers,
pubmed-meshheading:7633738-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:7633738-Case-Control Studies,
pubmed-meshheading:7633738-Cause of Death,
pubmed-meshheading:7633738-Cohort Studies,
pubmed-meshheading:7633738-Female,
pubmed-meshheading:7633738-Follow-Up Studies,
pubmed-meshheading:7633738-Forced Expiratory Volume,
pubmed-meshheading:7633738-Forecasting,
pubmed-meshheading:7633738-Glycoproteins,
pubmed-meshheading:7633738-Humans,
pubmed-meshheading:7633738-Male,
pubmed-meshheading:7633738-Middle Aged,
pubmed-meshheading:7633738-Phospholipids,
pubmed-meshheading:7633738-Proportional Hazards Models,
pubmed-meshheading:7633738-Proteolipids,
pubmed-meshheading:7633738-Pulmonary Fibrosis,
pubmed-meshheading:7633738-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:7633738-Pulmonary Surfactant-Associated Proteins,
pubmed-meshheading:7633738-Pulmonary Surfactants,
pubmed-meshheading:7633738-Smoking,
pubmed-meshheading:7633738-Survival Rate,
pubmed-meshheading:7633738-Total Lung Capacity,
pubmed-meshheading:7633738-Vital Capacity
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pubmed:year |
1995
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pubmed:articleTitle |
Surfactant protein A predicts survival in idiopathic pulmonary fibrosis.
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pubmed:affiliation |
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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