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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-9-13
|
| pubmed:abstractText |
A reversed-phase liquid chromatographic method with coulometric detection has been developed for the determination of free MKS 213-492 (a novel xanthine derivative) in plasma. This method is based on a simple and rapid plasma extraction procedure using precolumn-switching. The oxidation of this pharmacologically active xanthine derivative was optimized with respect to applied potential, pH of mobile and rinsing phase and rinsing time. The detection limit for MKS 213-492 was found to be 54 pg/injection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1572-6495
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
666
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
368-73
|
| pubmed:dateRevised |
2007-10-16
|
| pubmed:meshHeading |
pubmed-meshheading:7633616-Chromatography, High Pressure Liquid,
pubmed-meshheading:7633616-Electrochemistry,
pubmed-meshheading:7633616-Oxidation-Reduction,
pubmed-meshheading:7633616-Phosphodiesterase Inhibitors,
pubmed-meshheading:7633616-Reproducibility of Results,
pubmed-meshheading:7633616-Xanthines
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Determination of a novel xanthine derivative, MKS 213-492, in plasma by high-performance liquid chromatography with electrochemical detection.
|
| pubmed:affiliation |
EBEWE Pharmaceuticals, Unterach/Attersee, Austria.
|
| pubmed:publicationType |
Journal Article
|