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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
1995-9-13
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pubmed:abstractText |
A novel approach for the delivery of 166Ho (t1/2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo 166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to beta- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (+/- 7%) over a 20 h period, indicating no significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0969-8043
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
759-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7633391-Animals,
pubmed-meshheading:7633391-Bone Marrow,
pubmed-meshheading:7633391-Bone and Bones,
pubmed-meshheading:7633391-Dysprosium,
pubmed-meshheading:7633391-Holmium,
pubmed-meshheading:7633391-Humans,
pubmed-meshheading:7633391-Kinetics,
pubmed-meshheading:7633391-Mice,
pubmed-meshheading:7633391-Mice, Inbred BALB C,
pubmed-meshheading:7633391-Organometallic Compounds,
pubmed-meshheading:7633391-Pentetic Acid,
pubmed-meshheading:7633391-Radioisotopes,
pubmed-meshheading:7633391-Serum Albumin,
pubmed-meshheading:7633391-Tissue Distribution
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pubmed:year |
1995
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pubmed:articleTitle |
[166Dy]dysprosium/[166Ho]holmium in vivo generator.
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|
pubmed:affiliation |
Biomedicine and Health Program, Australian Nuclear Science and Technology Organisation (ANSTO), New South Wales.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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