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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-9-12
|
| pubmed:abstractText |
Sixteen children with biopsy-confirmed type I membranoproliferative glomerulonephritis (MPGN) were treated with six alternate-day intravenous pulses of methylprednisolone followed by single-dose alternate-day prednisone for 12-66 months (mean 37 months). The average length of follow-up was 52 months (range 12-127 months). Compared with pretreatment values, the frequency of hematuria (13/16 vs. 8/16, P < 0.05) and the levels of serum albumin (2.66 +/- 0.69 vs. 3.76 +/- 0.39 g/dl, P < 0.001), creatinine clearance (97 +/- 37 vs. 129 +/- 26 ml/min/1.73 m2, P < 0.001), and proteinuria (5.2 +/- 5.1 vs. 1.0 +/- 0.8 g/day, P < 0.001) were significantly improved after 3 months of therapy. Improvement has persisted through the end of the follow-up period. Repeat kidney biopsies showed a significant reduction in acute changes but an increase in chronic changes. Thirteen patients have been off therapy from 1 to 74 months (mean 20.8 months). Nine have a normal urinalysis, creatinine clearance, and protein excretion. The remainder have normal renal function but proteinuria ranging from 3.2 to 4.3 g/day. The data support the evidence of other investigators that corticosteroid therapy is beneficial in type I MPGN and suggest that initiation with pulse methylprednisolone may promote early stabilization of the disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0931-041X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
268-71
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7632508-Adolescent,
pubmed-meshheading:7632508-Child,
pubmed-meshheading:7632508-Child, Preschool,
pubmed-meshheading:7632508-Creatinine,
pubmed-meshheading:7632508-Drug Administration Schedule,
pubmed-meshheading:7632508-Drug Therapy, Combination,
pubmed-meshheading:7632508-Female,
pubmed-meshheading:7632508-Follow-Up Studies,
pubmed-meshheading:7632508-Glomerulonephritis, Membranoproliferative,
pubmed-meshheading:7632508-Humans,
pubmed-meshheading:7632508-Infusions, Intravenous,
pubmed-meshheading:7632508-Male,
pubmed-meshheading:7632508-Methylprednisolone,
pubmed-meshheading:7632508-Prednisone,
pubmed-meshheading:7632508-Proteinuria,
pubmed-meshheading:7632508-Retrospective Studies,
pubmed-meshheading:7632508-Serum Albumin,
pubmed-meshheading:7632508-Treatment Outcome
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Response of type I membranoproliferative glomerulonephritis to pulse methylprednisolone and alternate-day prednisone therapy.
|
| pubmed:affiliation |
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.
|
| pubmed:publicationType |
Journal Article
|