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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-9-6
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pubmed:abstractText |
Inherited resistance to activate protein C, which is caused by a single factor V gene mutation, is a frequent risk factor for thrombosis. The purpose of this study was to determine the prevalence of activated protein C resistance in women with thromboembolic complications that had occurred in connection with pregnancy or use of oral contraceptives.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/BLOOD PROTEINS,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/EMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Genetics,
http://linkedlifedata.com/resource/pubmed/keyword/Hemic System,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Scandinavia,
http://linkedlifedata.com/resource/pubmed/keyword/Sweden,
http://linkedlifedata.com/resource/pubmed/keyword/THROMBOEMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/Vascular Diseases
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9378
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
210-3
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pubmed:dateRevised |
2006-11-15
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pubmed:otherAbstract |
PIP: Inherited resistance to activated protein C, which is caused by a single factor V gene mutation, is a frequent risk factor for thrombosis. The authors determined the prevalence of activated protein C resistance in women with thromboembolic complications which had occurred in connection with pregnancy or the use of oral contraceptives. Activated protein C resistance was analyzed for 34 pregnancy-related complications, 28 oral contraceptive-related complications, in 57 health fertile women, and in 18 women during normal pregnancy. The women were of mean age 37.1 years in the range of 16-49 years. Activated protein C was found in almost 60% of women with thromboembolic complications during pregnancy and in approximately 30% of women with thromboembolic complications during treatment with oral contraceptives. Among nonpregnant controls, approximately 10% had activated protein C resistance. Activated protein C ratios were similar in normal pregnancy to those of normal controls. Since the single factor V gene mutation is common in the general population, the authors consider whether general screening for activated protein C resistance early during pregnancy or before prescription of oral contraceptives might be warranted.
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pubmed:meshHeading |
pubmed-meshheading:7631684-Adolescent,
pubmed-meshheading:7631684-Adult,
pubmed-meshheading:7631684-Contraceptives, Oral,
pubmed-meshheading:7631684-Factor V,
pubmed-meshheading:7631684-Female,
pubmed-meshheading:7631684-Humans,
pubmed-meshheading:7631684-Middle Aged,
pubmed-meshheading:7631684-Pregnancy,
pubmed-meshheading:7631684-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:7631684-Protein C,
pubmed-meshheading:7631684-Thromboembolism
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pubmed:year |
1995
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pubmed:articleTitle |
Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives.
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pubmed:affiliation |
Department of Obstetrics and Gynaecology, Mölndal Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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