Linked Life Data

7630250

Source:http://linkedlifedata.com/resource/pubmed/id/7630250

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8970
pubmed:dateCreated
1995-9-7
pubmed:abstractText
We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
346
pubmed:geneSymbol
5-HT2A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-2
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Association between clozapine response and allelic variation in 5-HT2A receptor gene.
pubmed:affiliation
Section of Molecular Genetics, Institute of Psychiatry, London, UK.
pubmed:publicationType
Journal Article, Comparative Study