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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1995-9-5
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pubmed:abstractText |
The t(8;21) is a frequent chromosome abnormality in acute myeloid leukemia (AML), particularly associated with M2 of the French-American-British (FAB) classification, but also found in a few patients with myelodysplastic syndrome (MDS). The two genes involved in the t(8;21) have been recently isolated and the cDNA of the AML1/ETO fusion gene identified. We have investigated a series of AML and MDS patients by a reverse transcriptase-polymerase chain reaction (RT-PCR) and analyzed the clinical and laboratory features of leukemia with t(8;21). The t(8;21) was only found in a subset of M2, which had the clinical and hematological features distinct from those M2 without t(8;21). M2 with t(8;21) was associated with a significantly higher myeloid differentiation and with a good response to chemotherapy. Moreover, among the patients with refractory anemia with excess of blasts in transformation (RAEB-T) the t(8;21) was also significantly associated with a higher myeloid differentiation and a good response to chemotherapy. M2 patients with t(8;21) could be distinguished on a number of hematological parameters, eg white blood cell count and percentage of bone marrow myeloblasts and promyelocytes, from RAEB-T carrying the t(8;21). Based on these findings we suggest that leukemia patients carrying t(8;21) can be grouped into two types; overt acute myeloid leukemia (M2) and smoldering or slowly evolving myeloid leukemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1T1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1147-53
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7630188-Adolescent,
pubmed-meshheading:7630188-Adult,
pubmed-meshheading:7630188-Aged,
pubmed-meshheading:7630188-Anemia, Refractory, with Excess of Blasts,
pubmed-meshheading:7630188-Base Sequence,
pubmed-meshheading:7630188-Bone Marrow,
pubmed-meshheading:7630188-Cell Differentiation,
pubmed-meshheading:7630188-Chromosomes, Human, Pair 21,
pubmed-meshheading:7630188-Chromosomes, Human, Pair 8,
pubmed-meshheading:7630188-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:7630188-DNA-Binding Proteins,
pubmed-meshheading:7630188-Female,
pubmed-meshheading:7630188-Granulocytes,
pubmed-meshheading:7630188-Humans,
pubmed-meshheading:7630188-Leukemia, Myeloid, Acute,
pubmed-meshheading:7630188-Leukocytosis,
pubmed-meshheading:7630188-Male,
pubmed-meshheading:7630188-Middle Aged,
pubmed-meshheading:7630188-Molecular Sequence Data,
pubmed-meshheading:7630188-Neoplasm Proteins,
pubmed-meshheading:7630188-Oncogene Proteins, Fusion,
pubmed-meshheading:7630188-Polymerase Chain Reaction,
pubmed-meshheading:7630188-Proto-Oncogene Proteins,
pubmed-meshheading:7630188-Transcription Factors,
pubmed-meshheading:7630188-Translocation, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
High degree of myeloid differentiation and granulocytosis is associated with t(8;21) smoldering leukemia.
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pubmed:affiliation |
Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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