| pubmed-article:7628883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7628883 | lifeskim:mentions | umls-concept:C2926606 | lld:lifeskim |
| pubmed-article:7628883 | lifeskim:mentions | umls-concept:C0018823 | lld:lifeskim |
| pubmed-article:7628883 | lifeskim:mentions | umls-concept:C2607943 | lld:lifeskim |
| pubmed-article:7628883 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:7628883 | lifeskim:mentions | umls-concept:C1456025 | lld:lifeskim |
| pubmed-article:7628883 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7628883 | pubmed:dateCreated | 1995-9-5 | lld:pubmed |
| pubmed-article:7628883 | pubmed:abstractText | Accelerated graft atherosclerosis is responsible for increased mortality and morbidity among heart transplant recipients. The aim of this in-vivo study was to evaluate coronary atherosclerotic vessel alterations and endothelial function. Seventeen patients (14 males; mean age 49.3 years; range 24 to 69) were studied an average of 11 weeks (range 5 to 21) after heart transplantation because of coronary artery disease (n = 8), dilative cardiomyopathy (n = 7), mitral valve replacement (n = 1) and left atrial metastases of a leiomyosarcoma (n = 1). Mean age of the donor hearts (9 males) was 29 years (range 12 to 55). All recipients underwent biplane ventriculography and coronary angiography. In this study population, a total of 120 coronary segments (main stem, 21; left anterior descending artery, 85; circumflex artery, 14) were analyzed by intravascular ultrasound (20 MHz, 3.5F). In 13 patients, acetylcholine was infused into the proximal left anterior descending artery (10(-8) to 10(-5) M) to evaluate vasomotion within this segment. Regional contraction abnormalities were documented in 2 patients. Nine segments angiographically showed non-critical stenoses (5 patients). Intravascular ultrasound detected 52 cross-sectional areas with a three-layer pattern indicating intimal thickening. Mean circumferential extension of intimal proliferation was 192 degrees, mean intimal thickness 0.35 mm. Only 5 segments of the sonographically pathological cross-sectional areas showed angiographical evidence of atherosclerotic lesions. Intracoronary administration of acetylcholine at doses of 10(-8) and 10(-7) M resulted in vasoconstriction of the examined coronary segment in only 2 patients; the intracoronary application of acetylcholine at doses of 10(-6) and 10(-5) M revealed coronary vasoconstriction in 10 of the total of 13 patients. Using intravascular ultrasound, coronary artery lesions in heart transplant recipients can already be depicted at a very early stage. The abnormal response to acetylcholine in most of the heart recipients is independent of the extent of atherosclerotic vessel abnormalities documented by ultrasound or angiography. | lld:pubmed |
| pubmed-article:7628883 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7628883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628883 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7628883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7628883 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7628883 | pubmed:issn | 0167-5273 | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:BreithardtGG | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:ScheldH HHH | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:BuddeTT | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:GOODF DFD | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:KerberSS | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:RahmelAA | lld:pubmed |
| pubmed-article:7628883 | pubmed:author | pubmed-author:Heinemann-Vec... | lld:pubmed |
| pubmed-article:7628883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7628883 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:7628883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7628883 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7628883 | pubmed:pagination | 119-29 | lld:pubmed |
| pubmed-article:7628883 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7628883 | pubmed:meshHeading | pubmed-meshheading:7628883-... | lld:pubmed |
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| pubmed-article:7628883 | pubmed:meshHeading | pubmed-meshheading:7628883-... | lld:pubmed |
| pubmed-article:7628883 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7628883 | pubmed:articleTitle | Angiographic, intravascular ultrasound and functional findings early after orthotopic heart transplantation. | lld:pubmed |
| pubmed-article:7628883 | pubmed:affiliation | Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms-University of Münster, Germany. | lld:pubmed |
| pubmed-article:7628883 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7628883 | lld:pubmed |
