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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-9-5
|
| pubmed:abstractText |
Accelerated graft atherosclerosis is responsible for increased mortality and morbidity among heart transplant recipients. The aim of this in-vivo study was to evaluate coronary atherosclerotic vessel alterations and endothelial function. Seventeen patients (14 males; mean age 49.3 years; range 24 to 69) were studied an average of 11 weeks (range 5 to 21) after heart transplantation because of coronary artery disease (n = 8), dilative cardiomyopathy (n = 7), mitral valve replacement (n = 1) and left atrial metastases of a leiomyosarcoma (n = 1). Mean age of the donor hearts (9 males) was 29 years (range 12 to 55). All recipients underwent biplane ventriculography and coronary angiography. In this study population, a total of 120 coronary segments (main stem, 21; left anterior descending artery, 85; circumflex artery, 14) were analyzed by intravascular ultrasound (20 MHz, 3.5F). In 13 patients, acetylcholine was infused into the proximal left anterior descending artery (10(-8) to 10(-5) M) to evaluate vasomotion within this segment. Regional contraction abnormalities were documented in 2 patients. Nine segments angiographically showed non-critical stenoses (5 patients). Intravascular ultrasound detected 52 cross-sectional areas with a three-layer pattern indicating intimal thickening. Mean circumferential extension of intimal proliferation was 192 degrees, mean intimal thickness 0.35 mm. Only 5 segments of the sonographically pathological cross-sectional areas showed angiographical evidence of atherosclerotic lesions. Intracoronary administration of acetylcholine at doses of 10(-8) and 10(-7) M resulted in vasoconstriction of the examined coronary segment in only 2 patients; the intracoronary application of acetylcholine at doses of 10(-6) and 10(-5) M revealed coronary vasoconstriction in 10 of the total of 13 patients. Using intravascular ultrasound, coronary artery lesions in heart transplant recipients can already be depicted at a very early stage. The abnormal response to acetylcholine in most of the heart recipients is independent of the extent of atherosclerotic vessel abnormalities documented by ultrasound or angiography.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0167-5273
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
119-29
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7628883-Acetylcholine,
pubmed-meshheading:7628883-Adolescent,
pubmed-meshheading:7628883-Adult,
pubmed-meshheading:7628883-Aged,
pubmed-meshheading:7628883-Child,
pubmed-meshheading:7628883-Coronary Angiography,
pubmed-meshheading:7628883-Coronary Artery Disease,
pubmed-meshheading:7628883-Coronary Vessels,
pubmed-meshheading:7628883-Endothelium, Vascular,
pubmed-meshheading:7628883-Female,
pubmed-meshheading:7628883-Heart Transplantation,
pubmed-meshheading:7628883-Humans,
pubmed-meshheading:7628883-Male,
pubmed-meshheading:7628883-Middle Aged,
pubmed-meshheading:7628883-Ultrasonography, Interventional,
pubmed-meshheading:7628883-Vasoconstriction,
pubmed-meshheading:7628883-Ventricular Function, Left,
pubmed-meshheading:7628883-Ventricular Pressure
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Angiographic, intravascular ultrasound and functional findings early after orthotopic heart transplantation.
|
| pubmed:affiliation |
Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms-University of Münster, Germany.
|
| pubmed:publicationType |
Journal Article
|