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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-9-7
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pubmed:databankReference |
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pubmed:abstractText |
We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
368
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7628632-Amino Acid Sequence,
pubmed-meshheading:7628632-Amino Acids,
pubmed-meshheading:7628632-Animals,
pubmed-meshheading:7628632-Base Sequence,
pubmed-meshheading:7628632-Blood,
pubmed-meshheading:7628632-Blood Proteins,
pubmed-meshheading:7628632-Cattle,
pubmed-meshheading:7628632-Chickens,
pubmed-meshheading:7628632-Cloning, Molecular,
pubmed-meshheading:7628632-DNA, Complementary,
pubmed-meshheading:7628632-Defensins,
pubmed-meshheading:7628632-Female,
pubmed-meshheading:7628632-Hemofiltration,
pubmed-meshheading:7628632-Humans,
pubmed-meshheading:7628632-Kidney,
pubmed-meshheading:7628632-Molecular Sequence Data,
pubmed-meshheading:7628632-Molecular Weight,
pubmed-meshheading:7628632-Sequence Analysis,
pubmed-meshheading:7628632-Sequence Analysis, DNA,
pubmed-meshheading:7628632-Sequence Homology, Amino Acid,
pubmed-meshheading:7628632-Vagina,
pubmed-meshheading:7628632-beta-Defensins
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pubmed:year |
1995
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pubmed:articleTitle |
hBD-1: a novel beta-defensin from human plasma.
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pubmed:affiliation |
Niedersächsisches Institut für Peptid-Forschung, Hannover, Germany.
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pubmed:publicationType |
Journal Article
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