|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021083,
umls-concept:C0022341,
umls-concept:C0034656,
umls-concept:C0546837,
umls-concept:C0596382,
umls-concept:C0681890,
umls-concept:C0936012,
umls-concept:C1257890,
umls-concept:C1514923,
umls-concept:C2603343,
umls-concept:C2745888
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|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1995-9-7
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|
pubmed:abstractText |
The aim of this report is to evaluate retrospectively the data from a prospective randomized study of 158 esophageal cancer patients who actually completed therapy with protein-bound polysaccharide P (PSK) and the 5-year survivals with and without raised alpha 1-antichymotrypsin and sialic acid levels to determine the value of these parameters in predicting effectiveness of immunotherapy. There was a significant difference in survival between the patients with and without PSK therapy. The survival of the radiochemotherapy plus PSK group treated for > 3 months was significantly better than that of the radiochemotherapy group. Among the patients with abnormal levels of alpha 1-antichymotrypsin and sialic acid, those who received PSK may have a significantly better survival than those without PSK. These results indicate that the preoperative serum levels of alpha 1-antichymotrypsin and sialic acid may possibly predict the effectiveness of immunotherapy using PSK.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0735-7907
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
363-9
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:7627722-Adult,
pubmed-meshheading:7627722-Aged,
pubmed-meshheading:7627722-Aged, 80 and over,
pubmed-meshheading:7627722-Antibiotics, Antineoplastic,
pubmed-meshheading:7627722-Combined Modality Therapy,
pubmed-meshheading:7627722-Esophageal Neoplasms,
pubmed-meshheading:7627722-Female,
pubmed-meshheading:7627722-Humans,
pubmed-meshheading:7627722-Immunologic Factors,
pubmed-meshheading:7627722-Immunotherapy,
pubmed-meshheading:7627722-Male,
pubmed-meshheading:7627722-Middle Aged,
pubmed-meshheading:7627722-N-Acetylneuraminic Acid,
pubmed-meshheading:7627722-Predictive Value of Tests,
pubmed-meshheading:7627722-Proteoglycans,
pubmed-meshheading:7627722-Retrospective Studies,
pubmed-meshheading:7627722-Sialic Acids,
pubmed-meshheading:7627722-Tumor Markers, Biological,
pubmed-meshheading:7627722-alpha 1-Antichymotrypsin
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|
pubmed:year |
1995
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|
pubmed:articleTitle |
Possible predictive markers of immunotherapy in esophageal cancer: retrospective analysis of a randomized study. The Cooperative Study Group for Esophageal Cancer in Japan.
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|
pubmed:affiliation |
Department of Surgery II, Tokai University, Kanagawa, Japan.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|
