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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1995-9-7
|
| pubmed:abstractText |
We studied the relationships between albuminuria, tissue factor-induced coagulation, and endothelial cell dysfunction in 67 patients with non-insulin-dependent diabetes mellitus (NIDDM) who were divided into three groups on the basis of their urinary albumin excretion rate (AER). To assess the early phase of tissue factor-induced coagulation, activated factor VII (FVIIa) levels in plasma were measured by a direct fluorogenic assay. As markers of endothelial cell dysfunction, levels of von Willebrand factor (vWF), tissue-type plasminogen activator-plasminogen activator inhibitor-1 (TPA-PAI-1) complex, PAI-1, and tissue factor pathway inhibitor (TFPI) were measured. FVIIa levels were increased in normoalbuminuric NIDDM patients (AER < 15 micrograms/min) when compared with normal control subjects. This FVIIa increase was accompanied by an increase in thrombin-antithrombin III complex (TAT) levels, indicating increased activation of coagulation even in normoalbuminuric patients. In NIDDM patients with microalbuminuria (AER = 15-200 micrograms/min), the FVIIa level, the FVIIa-FVII antigen (Ag) ratio (an indicator of activation of FVII zymogen to FVIIa), and the TAT level were further increased. This group also had higher levels of endothelial cell-derived factors (vWF, TPA-PAI-1 complex, and PAI-1) than the control group. The levels of endothelial cell-derived factors (including TFPI) were highest in the NIDDM patients with overt albuminuria (AER > 200 micrograms/min). In all 67 diabetic patients, AER showed a strong positive correlation with FVIIa (r = .574, P < .0001) and a weakly but still significant correlation with FVIIa-FVII:Ag (r = .365, P = .01), vWF (r = .315, P < .01), and TAT (r = .323, P < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1079-5642
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1114-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7627704-Adult,
pubmed-meshheading:7627704-Aged,
pubmed-meshheading:7627704-Blood Coagulation,
pubmed-meshheading:7627704-Blood Pressure,
pubmed-meshheading:7627704-Diabetes Mellitus, Type 2,
pubmed-meshheading:7627704-Diabetic Nephropathies,
pubmed-meshheading:7627704-Electrocardiography,
pubmed-meshheading:7627704-Endothelium, Vascular,
pubmed-meshheading:7627704-Enzyme Activation,
pubmed-meshheading:7627704-Factor VII,
pubmed-meshheading:7627704-Female,
pubmed-meshheading:7627704-Heart Diseases,
pubmed-meshheading:7627704-Humans,
pubmed-meshheading:7627704-Male,
pubmed-meshheading:7627704-Middle Aged,
pubmed-meshheading:7627704-Proteinuria,
pubmed-meshheading:7627704-Thromboplastin,
pubmed-meshheading:7627704-von Willebrand Factor
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Activation of tissue factor-induced coagulation and endothelial cell dysfunction in non-insulin-dependent diabetic patients with microalbuminuria.
|
| pubmed:affiliation |
Department of Internal Medicine, Awaji-Hokudan Pubic Clinic, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|