Linked Life Data

7626484

Source:http://linkedlifedata.com/resource/pubmed/id/7626484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-6
pubmed:dateCreated
1995-9-7
pubmed:abstractText
The factor(s) which regulate the rapid growth of ovarian epithelial carcinoma, as well as other types of malignant tumors, are still largely unknown. Recently, experimental evidence indicated that neoplastic cells are able to synthesize peptide growth factor and their receptors. This autocrine secretion could be one of the mechanisms to sustain their abnormal proliferation. In this study, we evaluated the possible role of basic fibroblast growth factor (bFGF) that is a likely candidate because it has both angiogenic and mitogenic activity and has been found in a variety of other neoplasms. As assessed by both bioassay and radioimmunoassay, a bFGF-like protein was present in seven ovarian epithelial neoplasms and in primary culture of dispersed ovarian cancer cells. Levels of this protein as well as its bioactivity varied in the different tumors examined. Reverse transcription-polymerase chain reaction indicated that the genes for bFGF and its receptor are expressed in all the samples studied. These data suggest that bFGF might be one of the growth factor regulating ovarian cancer cell proliferation through an autocrine mechanism. We are currently investigating whether the expression of this growth factor varies as a function of the histologic grade of the tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0960-0760
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Basic fibroblast growth factor and ovarian cancer.
pubmed:affiliation
Centro Auxologico Italiano IRCCS, University of Milano, Italy.
pubmed:publicationType
Journal Article