| pubmed-article:7626072 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C1522318 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0215825 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:7626072 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:7626072 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7626072 | pubmed:dateCreated | 1995-8-31 | lld:pubmed |
| pubmed-article:7626072 | pubmed:abstractText | Adrenomedullin (AM) is a newly identified vasorelaxant peptide which circulates in human plasma. We investigated the cellular mechanisms of AM-induced relaxation in the pig coronary artery, using fura-2 fluorometry and receptor-coupled membrane permeabilization by alpha-toxin. AM inhibited both the elevations of cytosolic Ca2+ concentration ([Ca2+]i) and the tension induced by high K(+)-depolarization and by U46619. The extent of the tension inhibition was much greater than expected based on the extent of reductions of [Ca2+]i. Thus, the [Ca2+]i (abscissa)-tension (ordinate) relation shifted to the right by AM. In alpha-toxin-permeabilized strips, AM decreased the tension development at constant [Ca2+]i (pCA 6.5) in the presence of GTP, whereas GDP beta S antagonized this effect. We thus conclude that AM relaxes the coronary artery not only by decreasing [Ca2]i but also by decreasing the Ca(2+)-sensitivity of the contractile apparatus, as mediated by G-protein. | lld:pubmed |
| pubmed-article:7626072 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7626072 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626072 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7626072 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7626072 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626072 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7626072 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7626072 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7626072 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7626072 | pubmed:author | pubmed-author:KobayashiSS | lld:pubmed |
| pubmed-article:7626072 | pubmed:author | pubmed-author:KanaideHH | lld:pubmed |
| pubmed-article:7626072 | pubmed:author | pubmed-author:NakanoTT | lld:pubmed |
| pubmed-article:7626072 | pubmed:author | pubmed-author:NishimuraJJ | lld:pubmed |
| pubmed-article:7626072 | pubmed:author | pubmed-author:KureishiYY | lld:pubmed |
| pubmed-article:7626072 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7626072 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:7626072 | pubmed:volume | 212 | lld:pubmed |
| pubmed-article:7626072 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7626072 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7626072 | pubmed:pagination | 572-9 | lld:pubmed |
| pubmed-article:7626072 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7626072 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7626072 | pubmed:articleTitle | Adrenomedullin decreases both cytosolic Ca2+ concentration and Ca(2+)-sensitivity in pig coronary arterial smooth muscle. | lld:pubmed |
| pubmed-article:7626072 | pubmed:affiliation | Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Japan. | lld:pubmed |
| pubmed-article:7626072 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7626072 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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