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rdf:type |
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lifeskim:mentions |
umls-concept:C0036667,
umls-concept:C0039005,
umls-concept:C0086045,
umls-concept:C0215825,
umls-concept:C0221464,
umls-concept:C0312418,
umls-concept:C0547047,
umls-concept:C0596235,
umls-concept:C1267092,
umls-concept:C1383501,
umls-concept:C1522318
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pubmed:issue |
2
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pubmed:dateCreated |
1995-8-31
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pubmed:abstractText |
Adrenomedullin (AM) is a newly identified vasorelaxant peptide which circulates in human plasma. We investigated the cellular mechanisms of AM-induced relaxation in the pig coronary artery, using fura-2 fluorometry and receptor-coupled membrane permeabilization by alpha-toxin. AM inhibited both the elevations of cytosolic Ca2+ concentration ([Ca2+]i) and the tension induced by high K(+)-depolarization and by U46619. The extent of the tension inhibition was much greater than expected based on the extent of reductions of [Ca2+]i. Thus, the [Ca2+]i (abscissa)-tension (ordinate) relation shifted to the right by AM. In alpha-toxin-permeabilized strips, AM decreased the tension development at constant [Ca2+]i (pCA 6.5) in the presence of GTP, whereas GDP beta S antagonized this effect. We thus conclude that AM relaxes the coronary artery not only by decreasing [Ca2]i but also by decreasing the Ca(2+)-sensitivity of the contractile apparatus, as mediated by G-protein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenomedullin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Endoperoxides...,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/guanosine 5'-O-(2-thiodiphosphate)
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
572-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7626072-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:7626072-Adrenomedullin,
pubmed-meshheading:7626072-Animals,
pubmed-meshheading:7626072-Calcium,
pubmed-meshheading:7626072-Coronary Vessels,
pubmed-meshheading:7626072-Cytosol,
pubmed-meshheading:7626072-Electrophysiology,
pubmed-meshheading:7626072-GTP-Binding Proteins,
pubmed-meshheading:7626072-Guanosine Diphosphate,
pubmed-meshheading:7626072-Guanosine Triphosphate,
pubmed-meshheading:7626072-Muscle, Smooth, Vascular,
pubmed-meshheading:7626072-Muscle Contraction,
pubmed-meshheading:7626072-Muscle Relaxation,
pubmed-meshheading:7626072-Peptides,
pubmed-meshheading:7626072-Permeability,
pubmed-meshheading:7626072-Potassium,
pubmed-meshheading:7626072-Prostaglandin Endoperoxides, Synthetic,
pubmed-meshheading:7626072-Swine,
pubmed-meshheading:7626072-Thionucleotides,
pubmed-meshheading:7626072-Thromboxane A2,
pubmed-meshheading:7626072-Type C Phospholipases,
pubmed-meshheading:7626072-Vasoconstrictor Agents
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pubmed:year |
1995
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pubmed:articleTitle |
Adrenomedullin decreases both cytosolic Ca2+ concentration and Ca(2+)-sensitivity in pig coronary arterial smooth muscle.
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pubmed:affiliation |
Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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