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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-8-29
|
| pubmed:abstractText |
Carbohydrate metabolism was assessed in 20 glucose-intolerant subjects before and after 12 wk on a high-carbohydrate diet (HC) or the diet combined with exercise training (HC-EX). The diet provided 60% of energy as carbohydrate and 20% as fat. Neither treatment altered fasting glucose or insulin concentrations or their response to a meal. During a glucose clamp (216 pmol insulin/L) glucose disposal increased from 13.2 +/- 0.83 to 14.6 +/- 0.83 mumol.kg fat-free mass-1.min-1 (P < 0.05) in both groups. During more pronounced hyperinsulinemia (654 pmol/L) glucose disposal did not change significantly (49.9 +/- 3.8 to 50.7 +/- 3.8 mumol.kg fat-free mass-1.min-1). Muscle glycogen increased in the HC-EX group (78.5 +/- 8.1 to 161.1 +/- 15.7 mmol glucose/kg muscle), with no changes in the HC group. These results do not support the recommendation to increase the dietary carbohydrate content for improving postprandial glucose metabolism or insulin action in glucose-intolerant adults unless combined with exercise training, which promotes muscle glycogen storage.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0002-9165
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
426-33
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7625352-Aged,
pubmed-meshheading:7625352-Aging,
pubmed-meshheading:7625352-Blood Glucose,
pubmed-meshheading:7625352-Body Composition,
pubmed-meshheading:7625352-Dietary Carbohydrates,
pubmed-meshheading:7625352-Dose-Response Relationship, Drug,
pubmed-meshheading:7625352-Energy Metabolism,
pubmed-meshheading:7625352-Exercise,
pubmed-meshheading:7625352-Female,
pubmed-meshheading:7625352-Glucose Clamp Technique,
pubmed-meshheading:7625352-Glucose Tolerance Test,
pubmed-meshheading:7625352-Glycogen,
pubmed-meshheading:7625352-Humans,
pubmed-meshheading:7625352-Hyperinsulinism,
pubmed-meshheading:7625352-Insulin,
pubmed-meshheading:7625352-Insulin Resistance,
pubmed-meshheading:7625352-Male,
pubmed-meshheading:7625352-Middle Aged,
pubmed-meshheading:7625352-Muscle, Skeletal,
pubmed-meshheading:7625352-Time Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance.
|
| pubmed:affiliation |
US Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Controlled Clinical Trial
|