Linked Life Data

7623970

Source:http://linkedlifedata.com/resource/pubmed/id/7623970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-8-31
pubmed:abstractText
The ultrastructural change brought about by administration of oestrogens on articular cartilage were evaluated in the course of the present study. To this end 3 stabilized postmenopausal patients were selected who were to undergo bilateral hip prosthesis. After the first operation the patients were started on continuous estriol treatment by oral route for 6 months. For study purposes a cartilage fragment was obtained during the first (baseline time) operation and the second operation (final time, after 6 months of oestrogen therapy). The results of histologic examination of the semifine sections as well as the submicroscopic patterns of the various cell elements showed great similarity in all cases considered. Ultrastructure examination had evidenced signs of marked cell damage in the 3 initial samples. After treatment with oestrogens, chondrocyte metabolic activity was resumed, evidenced by the presence of extensive granular endoplasmic reticulum with hypertrophic cisternae, finely dispersed nuclear chromatin and more regular nuclear membrane. These findings would appear to support metabolic stimulation of articular cartilage by the oestrogens.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0026-4806
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Estrogens and cartilage: an ex vivo ultrastructural study].
pubmed:affiliation
Istituto di Reumatologia, Università degli Studi, Siena.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract