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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-8-29
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pubmed:abstractText |
Biochemical purification and cognate cDNA cloning studies have revealed that the previously described transcriptional coactivator OCA-B consists of a 34- or 35-kDa polypeptide with sequence relationships to known coactivators that function by protein-protein interactions. Studies with a recombinant protein have proved that a single OCA-B polypeptide is the main determinant for B-cell-specific activation of immunoglobulin (Ig) promoters and provided additional insights into its mechanism of action. Recombinant OCA-B can function equally well with Oct-1 or Oct-2 on an Ig promoter, but while corresponding POU domains are sufficient for OCA-B interaction, and for octamer-mediated transcription of a histone H2B promoter, an additional Oct-1 or Oct-2 activation domain(s) is necessary for functional synergy with OCA-B. Further studies additional Oct-1 or Oct-2 activation domain(s) is necessary for functional synergy with OCA-B. Further studies show that Ig promoter activation by Oct-1 and OCA-B requires still other general (USA-derived) cofactors and also provide indirect evidence that distinct Oct-interacting cofactors regulate H2B transcription.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1358755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1423591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1535687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1620119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1638634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1781030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1830243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1889091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1910683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1923818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1979524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-1991317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2044958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2123291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2124519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2233708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2302733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2328728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2328729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2568852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-2667136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-3215510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-3317825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-7600290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-7600291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-7813434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-7870180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-7913207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8001121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8062391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8062392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8096198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8139685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8334992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8388484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7623806-8422989
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HCFC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Host Cell Factor C1,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/POU2AF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4115-24
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7623806-Amino Acid Sequence,
pubmed-meshheading:7623806-B-Lymphocytes,
pubmed-meshheading:7623806-Cell Differentiation,
pubmed-meshheading:7623806-Cloning, Molecular,
pubmed-meshheading:7623806-DNA, Complementary,
pubmed-meshheading:7623806-DNA-Binding Proteins,
pubmed-meshheading:7623806-Histones,
pubmed-meshheading:7623806-Host Cell Factor C1,
pubmed-meshheading:7623806-Humans,
pubmed-meshheading:7623806-Immunoglobulins,
pubmed-meshheading:7623806-Models, Genetic,
pubmed-meshheading:7623806-Molecular Sequence Data,
pubmed-meshheading:7623806-Octamer Transcription Factor-1,
pubmed-meshheading:7623806-Promoter Regions, Genetic,
pubmed-meshheading:7623806-Protein Binding,
pubmed-meshheading:7623806-Tissue Distribution,
pubmed-meshheading:7623806-Trans-Activators,
pubmed-meshheading:7623806-Transcription, Genetic,
pubmed-meshheading:7623806-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B.
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pubmed:affiliation |
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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