7622220

pubmed:Citation

8

Previous work in our laboratory has shown that corticosterone increases the susceptibility of macrophages from Bcgs mice to the growth of Mycobacterium avium. The innate antimycobacterial activity of macrophages from Bcgr mice was not affected by corticosterone. In contrast to the differential effect of corticosterone on the antimycobacterial activity of the macrophages, corticosterone suppressed the production of tumor necrosis factor alpha and nitric oxide by macrophages from both Bcgr and Bcgs mice. The purpose of this investigation was to compare the effects of corticosterone on the antimycobacterial activity of macrophages from Bcgr and Bcgs mice that have been activated in vitro with recombinant gamma interferon or granulocyte-macrophage colony-stimulating factor. We found that macrophages from both strains of congenic mice responded equally to the activation stimuli. The capacity of the activated macrophages from Bcgs mice to suppress the growth of M. avium was inhibited by the addition of corticosterone to the cultures. The addition of NG-monomethyl-L-arginine to the cultures did not affect the capacity of resident splenic macrophages from Bcgr mice to limit the growth of M. avium. However, NG-monomethyl-L-arginine reduced the capacity of gamma interferon-activated, but not granulocyte-macrophage colony-stimulating factor-activated, macrophages to limit the growth of M. avium by macrophages from both Bcgr and Bcgs mice. The addition of corticosterone suppressed Nramp expression by macrophages from Bcgs mice. Nramp expression by macrophages from Bcgr mice was not affected by corticosterone.

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http://linkedlifedata.com/resource/pubmed/journal/0246127

http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cation Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage..., http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Iron-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/natural resistance-associated..., http://linkedlifedata.com/resource/pubmed/chemical/solute carrier family 11-...

Aug

pubmed-author:BrownD HDH, pubmed-author:LaFuseWW, pubmed-author:ZwillingB SBS

63

NLM

2983-8

pubmed-meshheading:7622220-Animals, pubmed-meshheading:7622220-Mice, pubmed-meshheading:7622220-Tuberculosis, pubmed-meshheading:7622220-Nitric Oxide, pubmed-meshheading:7622220-Male, pubmed-meshheading:7622220-Mycobacterium avium, pubmed-meshheading:7622220-Macrophages, pubmed-meshheading:7622220-Mycobacterium bovis, pubmed-meshheading:7622220-Membrane Proteins, pubmed-meshheading:7622220-Mice, Inbred Strains, pubmed-meshheading:7622220-Base Sequence, pubmed-meshheading:7622220-Corticosterone, pubmed-meshheading:7622220-Mice, Inbred BALB C, pubmed-meshheading:7622220-Molecular Sequence Data, pubmed-meshheading:7622220-Iron-Binding Proteins, pubmed-meshheading:7622220-Carrier Proteins, pubmed-meshheading:7622220-Recombinant Proteins, pubmed-meshheading:7622220-Cation Transport Proteins, pubmed-meshheading:7622220-Interferon-gamma, pubmed-meshheading:7622220-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:7622220-Macrophage Activation