| pubmed-article:7621884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0054961 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C0015295 | lld:lifeskim |
| pubmed-article:7621884 | lifeskim:mentions | umls-concept:C2924612 | lld:lifeskim |
| pubmed-article:7621884 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7621884 | pubmed:dateCreated | 1995-8-29 | lld:pubmed |
| pubmed-article:7621884 | pubmed:abstractText | CD45 is a receptor-type protein tyrosine phosphatase involved in the regulation of lymphocyte activation. Different CD45 isoforms are generated by alternative splicing of three variable exons (A, B and C). The pattern of CD45 splicing depends upon cell type and state of activation. CD45RA isoforms (containing exon A-encoded sequences) can usually be found on a subset of resting T cells, but not on activated T cells. We have recently described a variant pattern of CD45RA expression which is characterized by continuous expression of CD45RA molecules on activated and memory T cells. Here, we demonstrate that this phenotype is associated with heterozygosity for a point mutation at nucleotide position 77 of exon A, leading to a C-->G transition. This mutation does not change the protein sequence of the CD45RA isoform. We conclude that position 77 is part of a motif necessary for splicing of exon A, which supports the hypothesis that sequences within exons have significant effects on alternative splicing. The mutation of this motif might prevent binding of a transacting splice factor. In the heterozygous state, this mutation is not associated with impaired T cell reactivity. Functional consequences of the homozygous state remain to be elucidated. | lld:pubmed |
| pubmed-article:7621884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7621884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7621884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7621884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7621884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7621884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7621884 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7621884 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:7621884 | pubmed:author | pubmed-author:WonigeitKK | lld:pubmed |
| pubmed-article:7621884 | pubmed:author | pubmed-author:SchwinzerRR | lld:pubmed |
| pubmed-article:7621884 | pubmed:author | pubmed-author:HundrieserJJ | lld:pubmed |
| pubmed-article:7621884 | pubmed:author | pubmed-author:ThudeHH | lld:pubmed |
| pubmed-article:7621884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7621884 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7621884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7621884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7621884 | pubmed:pagination | 2101-6 | lld:pubmed |
| pubmed-article:7621884 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:meshHeading | pubmed-meshheading:7621884-... | lld:pubmed |
| pubmed-article:7621884 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7621884 | pubmed:articleTitle | A point mutation in the human CD45 gene associated with defective splicing of exon A. | lld:pubmed |
| pubmed-article:7621884 | pubmed:affiliation | Klinik für Abdominal- und Transplantationschirurgie Medizinische Hochschule Hannover, Hannover, Germany. | lld:pubmed |
| pubmed-article:7621884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7621884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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