Linked Life Data

7621771

Source:http://linkedlifedata.com/resource/pubmed/id/7621771

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-8-30
pubmed:abstractText
Deviant tones embedded in a sequence of standard tones elicit an event-related potential (ERP) component called the mismatch negativity (MMN), which reflects automatic stimulus change detection in the human auditory system. To determine whether stimulus change detection is impaired in Parkinson's disease (PD), we recorded ERPs in 13 non-demented patients with PD and in 11 age-matched healthy control subjects both when tones were attended and when they were unattended. The difference area between deviant and standard ERPs was used to evaluate the MMN in the 'unattended' condition. The MMN was significantly smaller in patients with PD than in controls. In the attended condition, the amplitudes of both N1 and the N2 complex were smaller in the patient group than in controls. MMN attenuation suggests that PD patients have impaired automatic stimulus change detection compared with healthy controls. This might be caused by dopamine deficiency in PD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-52
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Automatic auditory discrimination is impaired in Parkinson's disease.
pubmed:affiliation
Department of Neurology, University Hospital of Kuopio, Finland.
pubmed:publicationType
Journal Article