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rdf:type |
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lifeskim:mentions |
umls-concept:C0009447,
umls-concept:C0024264,
umls-concept:C0039194,
umls-concept:C0237753,
umls-concept:C0243067,
umls-concept:C0301630,
umls-concept:C0678226,
umls-concept:C0871261,
umls-concept:C1332714,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1995-8-30
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pubmed:abstractText |
T cells from patients with CVID have defects that may relate to the failure in vivo of B cell production of antibodies. Antigen-driven responses of T cells from CVID patients and normal subjects have been assessed by measuring DNA synthesis in vitro. Low density cells enriched for antigen-presenting dendritic cells were pulsed with purified protein derivative (PPD) and cultured with autologous T cells. Overall, T cells from CVID patients showed a significantly low mean response to PPD, although non-specific DNA synthesis induced in CVID T cells by IL-2 was within the normal range. However, mean PPD-specific T cell responses in CVID were not restored by IL-2 irrespective of the presence of monocytes. Depletion of CD8+ cells also failed to restore the mean PPD response of CVID CD4+ T cells. Limiting dilution analysis showed that in CVID there was a reduced frequency of antigen-specific cells within the T cell preparations. The mean frequency of the PPD-specific T cells in cultures from patients vaccinated with bacille Calmette-Guérin (BCG) was reduced to 1 in 109,000 T cells compared with 1 in 18,600 T cells in BCG-vaccinated normal donors. These data show that the reduced PPD-specific response in CVID is due to a partial peripheral loss of antigen-specific cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1315323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1396968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1457964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1458779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1510837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1604242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1606751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1616898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1638764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1826647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-1863999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-2078333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-2165880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-2573059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-2784795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-2805402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-3007336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-3529367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-4549712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-6213861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-6611349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-6976384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-7373063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-7679486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-7905793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-7913365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-8149665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7621598-8306493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7621598-Adult,
pubmed-meshheading:7621598-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7621598-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7621598-Cells, Cultured,
pubmed-meshheading:7621598-Common Variable Immunodeficiency,
pubmed-meshheading:7621598-Humans,
pubmed-meshheading:7621598-Immunoglobulin G,
pubmed-meshheading:7621598-Immunoglobulin M,
pubmed-meshheading:7621598-Interleukin-2,
pubmed-meshheading:7621598-Lymphocyte Activation,
pubmed-meshheading:7621598-Mycobacterium bovis,
pubmed-meshheading:7621598-Tuberculin
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pubmed:year |
1995
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pubmed:articleTitle |
Defects in antigen-driven lymphocyte responses in common variable immunodeficiency (CVID) are due to a reduction in the number of antigen-specific CD4+ T cells.
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pubmed:affiliation |
Department of Clinical Immunology, Royal Free Hospital School of Medicine, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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