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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1979-4-28
|
| pubmed:abstractText |
Two photoactivable derivatives of tetrodotoxin have been synthesized. Electrophysiological experiments on crab giant axons and competitive binding with [3H]-tetrodotoxin for the tetrodotoxin receptor indicate that they are only 4.5 to 7.5 times less active than tetrodotoxin itself. These compounds give a reversible block of the sodium channel in the dark but after ultraviolet irradiation they provoke an irreversible blockade of the channel.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
254
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1552-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:762156-Animals,
pubmed-meshheading:762156-Axons,
pubmed-meshheading:762156-Binding, Competitive,
pubmed-meshheading:762156-Brachyura,
pubmed-meshheading:762156-Cell Membrane,
pubmed-meshheading:762156-Kinetics,
pubmed-meshheading:762156-Protein Binding,
pubmed-meshheading:762156-Receptors, Drug,
pubmed-meshheading:762156-Tetrodotoxin,
pubmed-meshheading:762156-Ultraviolet Rays
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
Synthesis and mode of action on axonal membranes of photoactivable derivatives of tetrodotoxin.
|
| pubmed:publicationType |
Journal Article
|