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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-8-31
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pubmed:abstractText |
We studied the effect of Saiboku-to (TJ-96), an anti-allergic herbal medicine, on transepithelial potential difference of rabbit trachea and possible involvement of nitric oxide (NO) generation in vivo. Perfusion of TJ-96 on the tracheal mucosal surface increased PD in a concentration-dependent manner, the maximal increase from the baseline level and the concentration of TJ-96 required to produce a half-maximal effect (EC50) being 8.1 +/- 1.4 mV (mean +/- SE, P < 0.001) and 47 micrograms/ml. This effect was abolished by pretreatment with the Na channel blocker amiloride. NG-nitro-L-arginine methylester (L-NAME) but not NG-nitro-D-arginine methylester (D-NAME) inhibited TJ-96-induced increase in PD, and this inhibition was selectively reversed by L-arginine. These results suggest that TJ-96 stimulates Na absorption by airway epithelial cells probably through NO generation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-50
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7620837-Amiloride,
pubmed-meshheading:7620837-Animals,
pubmed-meshheading:7620837-Arginine,
pubmed-meshheading:7620837-Drugs, Chinese Herbal,
pubmed-meshheading:7620837-Epithelium,
pubmed-meshheading:7620837-Histamine H1 Antagonists,
pubmed-meshheading:7620837-Hypersensitivity,
pubmed-meshheading:7620837-Male,
pubmed-meshheading:7620837-Medicine, Kampo,
pubmed-meshheading:7620837-Membrane Potentials,
pubmed-meshheading:7620837-Mucous Membrane,
pubmed-meshheading:7620837-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:7620837-Nitric Oxide,
pubmed-meshheading:7620837-Rabbits,
pubmed-meshheading:7620837-Sodium,
pubmed-meshheading:7620837-Trachea
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pubmed:year |
1995
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pubmed:articleTitle |
Effect of TJ-96, an anti-allergic herbal medicine, on tracheal transepithelial potential difference in vivo.
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pubmed:affiliation |
First Department of Medicine, Tokyo Women's Medical College, Japan.
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pubmed:publicationType |
Journal Article
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