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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1995-8-31
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pubmed:abstractText |
The clinical efficacy and safety of bevantolol hydrochloride, a newly developed beta-blocker, used in combination with other types of antihypertensive agents, were evaluated in patients with severe hypertension by multicenter open-label trials. A total of 28 patients were studied at 20 medical centers. Four patients (14.3%) were excluded for some reasons, and the remaining 24 patients (22 outpatients and 2 inpatients) were analyzed. Following the initiation of therapy, blood pressure decreased from 181 +/- 15 (SD)/114 +/- 3 mmHg to 170 +/- 17/102 +/- 8 mmHg (p < 0.01) on the 14th day of the therapy and gradually lowered further thereafter. At the end of the trial (8th week), blood pressure was stabilized at the level of 160 +/- 14/96 +/- 10 mmHg. The antihypertensive efficacy rated by the changes in mean blood pressure was 79.2% (19/24). Pulse rate decreased slightly but significantly from 75 +/- 10 beats/min to 70 +/- 7 (p < 0.05) on the 14th day of the therapy and stabilized at the similar level thereafter. As abnormal laboratory data were detected in 3 patients and 1 patient complained of a mild headache, the safety ratio was 83.3% (20/24 patients). When the usefulness was assessed in terms of antihypertensive efficacy and safety profiles, bevantolol hydrochloride was considered useful in 75.0% of the patients studied. In conclusion, bevantolol hydrochloride, used in combination with other classes of antihypertensive agents, appears to be an excellent drug for the management of patients with severe hypertension.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0946-1965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7620695-Adrenergic beta-Antagonists,
pubmed-meshheading:7620695-Adult,
pubmed-meshheading:7620695-Aged,
pubmed-meshheading:7620695-Blood Chemical Analysis,
pubmed-meshheading:7620695-Blood Pressure,
pubmed-meshheading:7620695-Body Weight,
pubmed-meshheading:7620695-Diuresis,
pubmed-meshheading:7620695-Drug Evaluation,
pubmed-meshheading:7620695-Drug Therapy, Combination,
pubmed-meshheading:7620695-Electrocardiography,
pubmed-meshheading:7620695-Heart Rate,
pubmed-meshheading:7620695-Humans,
pubmed-meshheading:7620695-Hypertension,
pubmed-meshheading:7620695-Inpatients,
pubmed-meshheading:7620695-Liver Function Tests,
pubmed-meshheading:7620695-Middle Aged,
pubmed-meshheading:7620695-Outpatients,
pubmed-meshheading:7620695-Propanolamines
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pubmed:year |
1995
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pubmed:articleTitle |
Clinical evaluation of bevantolol hydrochloride in patients with severe hypertension. The Cooperative Study Group on Bevantolol in Japan.
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pubmed:affiliation |
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Multicenter Study
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