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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-8-30
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pubmed:abstractText |
Both pre- and postsynaptic protein kinase C have been implicated in long-term potentiation. Neurogranin (also known as BICKs and RC3) is a neuronal postsynaptic protein kinase C substrate. In the present study we injected monoclonal IgGs that recognize the protein kinase C phosphorylation site in neurogranin and B-50 (GAP-43), and that have been shown to inhibit protein kinase C-mediated B-50 phosphorylation, through a whole-cell clamp pipette into CA1 pyramidal neurons in rat hippocampal slices. Injection of neurogranin IgGs, but not of control IgGs, prevented the induction of tetanus-induced long-term potentiation without affecting post-tetanic potentiation. Our results suggest that neurogranin is involved in mechanisms of activity-dependent synaptic plasticity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAP-43 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurofilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurogranin,
http://linkedlifedata.com/resource/pubmed/chemical/Nrgn protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
819-22
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7620629-Animals,
pubmed-meshheading:7620629-Antibodies, Monoclonal,
pubmed-meshheading:7620629-Calmodulin-Binding Proteins,
pubmed-meshheading:7620629-Evoked Potentials,
pubmed-meshheading:7620629-GAP-43 Protein,
pubmed-meshheading:7620629-Hippocampus,
pubmed-meshheading:7620629-Immunoglobulin G,
pubmed-meshheading:7620629-Long-Term Potentiation,
pubmed-meshheading:7620629-Male,
pubmed-meshheading:7620629-Membrane Glycoproteins,
pubmed-meshheading:7620629-Nerve Tissue Proteins,
pubmed-meshheading:7620629-Neurofilament Proteins,
pubmed-meshheading:7620629-Neurogranin,
pubmed-meshheading:7620629-Neuronal Plasticity,
pubmed-meshheading:7620629-Neurons,
pubmed-meshheading:7620629-Patch-Clamp Techniques,
pubmed-meshheading:7620629-Protein Kinase C,
pubmed-meshheading:7620629-Pyramidal Cells,
pubmed-meshheading:7620629-Rats,
pubmed-meshheading:7620629-Rats, Wistar,
pubmed-meshheading:7620629-Synapses,
pubmed-meshheading:7620629-Synaptic Transmission
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pubmed:year |
1995
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pubmed:articleTitle |
Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons.
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pubmed:affiliation |
Department of Neurophysiology, Institute for Neurobiology, Magdeburg, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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