Linked Life Data

7620242

Source:http://linkedlifedata.com/resource/pubmed/id/7620242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-8-30
pubmed:abstractText
A ventilated perfused model of rat lung is described enabling continuous simultaneous measurement of pulmonary perfusion pressure (PPP), pulmonary inflation pressure (PIP) and lung weight. The preparation was stable for 2h before oedema formation commenced. Phenylephrine injected into the pulmonary artery produced selective increases in PPP (ED50 4.0 +/- 0.7 nmol, n = 5) without affecting airway tone or lung weight. Carbachol under basal perfusion conditions caused bronchoconstriction (ED50 4.25 +/- 0.4 nmol, n = 7) without affecting PPP and lung weight. Bradykinin (BK) caused increases in PPP (ED50 22 +/- 3 nmol, n = 8), lung weight and PIP (ED50 35.6 +/- 3.6 nmol, n = 8). Low doses of BK (25-50 nmol) caused increases in lung weight which were reversible. Higher doses (100-200 pmol) caused irreversible increases in lung weight which albumin-bound dye infusion showed were associated with albumin accumulation. Manipulation of venous outflow pressure revealed that the changes in lung weight induced by BK were potentially explicable as sequelae of vascular hydrostatic pressure changes possibly resulting from venoconstriction. It is concluded that this model is useful for studying drug actions on bronchial tone, pulmonary vasculature tone and vascular permeability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0952-0600
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Differential effects of agents on bronchial and vascular tone and lung weight in the rat isolated perfused lung.
pubmed:affiliation
Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't