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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1979-4-26
|
| pubmed:abstractText |
Investigations on the Nin-formyl group as a protecting group of the tryptophan indole side chain under the conditions of conventional peptide synthesis using model compounds are described. The protecting group prevents the tert-butylation of tryptophan residues during acidolytic removal of tert-butyloxycarbonyl groups and allows the preparation of tryptophan tert-butylester in good yields. However, because of the observed side reactions, as hydrogenation of the indole to a 2,3-dihydroindole side chain, instability of the protecting group under various experimental conditions, the Nin-formyl group is only of limited use in peptide synthesis.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0018-4888
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
360
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1979
|
| pubmed:articleTitle |
[Studies on the Nin-formyl group as possible protecting group against tryptophan indole side chain tert-butylation (author's transl)].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|