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pubmed-article:7618083pubmed:abstractTextThe Rac guanosine 5'-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the approximately 65- and approximately 68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phosphorylated the p47phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity.lld:pubmed
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pubmed-article:7618083pubmed:articleTitleRegulation of human leukocyte p21-activated kinases through G protein--coupled receptors.lld:pubmed
pubmed-article:7618083pubmed:affiliationDepartment of Immunology, Scrippts Research Institute, La Jolla, CA 92037, USA.lld:pubmed
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