pubmed-article:7618083 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7618083 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:7618083 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
pubmed-article:7618083 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
pubmed-article:7618083 | lifeskim:mentions | umls-concept:C1955933 | lld:lifeskim |
pubmed-article:7618083 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:7618083 | pubmed:issue | 5221 | lld:pubmed |
pubmed-article:7618083 | pubmed:dateCreated | 1995-8-22 | lld:pubmed |
pubmed-article:7618083 | pubmed:abstractText | The Rac guanosine 5'-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the approximately 65- and approximately 68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phosphorylated the p47phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity. | lld:pubmed |
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pubmed-article:7618083 | pubmed:language | eng | lld:pubmed |
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pubmed-article:7618083 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:7618083 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7618083 | pubmed:month | Jul | lld:pubmed |
pubmed-article:7618083 | pubmed:issn | 0036-8075 | lld:pubmed |
pubmed-article:7618083 | pubmed:author | pubmed-author:MorrisSS | lld:pubmed |
pubmed-article:7618083 | pubmed:author | pubmed-author:BokochG MGM | lld:pubmed |
pubmed-article:7618083 | pubmed:author | pubmed-author:KnausU GUG | lld:pubmed |
pubmed-article:7618083 | pubmed:author | pubmed-author:DongH JHJ | lld:pubmed |
pubmed-article:7618083 | pubmed:author | pubmed-author:ChernoffJJ | lld:pubmed |
pubmed-article:7618083 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7618083 | pubmed:day | 14 | lld:pubmed |
pubmed-article:7618083 | pubmed:volume | 269 | lld:pubmed |
pubmed-article:7618083 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7618083 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7618083 | pubmed:pagination | 221-3 | lld:pubmed |
pubmed-article:7618083 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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pubmed-article:7618083 | pubmed:year | 1995 | lld:pubmed |
pubmed-article:7618083 | pubmed:articleTitle | Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. | lld:pubmed |
pubmed-article:7618083 | pubmed:affiliation | Department of Immunology, Scrippts Research Institute, La Jolla, CA 92037, USA. | lld:pubmed |
pubmed-article:7618083 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:7618083 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:7618083 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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