|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5221
|
|
pubmed:dateCreated |
1995-8-22
|
|
pubmed:abstractText |
The Rac guanosine 5'-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the approximately 65- and approximately 68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phosphorylated the p47phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella,
http://linkedlifedata.com/resource/pubmed/chemical/neutrophil cytosolic factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/p21-Activated Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
14
|
|
pubmed:volume |
269
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
221-3
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7618083-Adenosine Triphosphate,
pubmed-meshheading:7618083-Enzyme Activation,
pubmed-meshheading:7618083-GTP-Binding Proteins,
pubmed-meshheading:7618083-Guanosine Triphosphate,
pubmed-meshheading:7618083-Humans,
pubmed-meshheading:7618083-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:7618083-NADH, NADPH Oxidoreductases,
pubmed-meshheading:7618083-NADPH Dehydrogenase,
pubmed-meshheading:7618083-NADPH Oxidase,
pubmed-meshheading:7618083-Neutrophil Activation,
pubmed-meshheading:7618083-Neutrophils,
pubmed-meshheading:7618083-Pertussis Toxin,
pubmed-meshheading:7618083-Phosphoproteins,
pubmed-meshheading:7618083-Phosphorylation,
pubmed-meshheading:7618083-Protein-Serine-Threonine Kinases,
pubmed-meshheading:7618083-Recombinant Proteins,
pubmed-meshheading:7618083-Tetradecanoylphorbol Acetate,
pubmed-meshheading:7618083-Virulence Factors, Bordetella,
pubmed-meshheading:7618083-p21-Activated Kinases,
pubmed-meshheading:7618083-rac GTP-Binding Proteins
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors.
|
|
pubmed:affiliation |
Department of Immunology, Scrippts Research Institute, La Jolla, CA 92037, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
