Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1995-8-18
|
pubmed:abstractText |
The efficacy and tolerability of moclobemide (300-600 mg daily) and fluoxetine (20-40 mg daily) were compared in a 6-week, double-blind study of 65 inpatients and 34 outpatients suffering from major depressive episodes (DSM III-R). No statistically significant differences between the two treatment groups were noted regarding efficacy (HDRS, CGI) or safety (adverse events, laboratory examination, vital signs). Moclobemide (300-600 mg daily) and fluoxetine (20-40 mg daily) would thus appear to be comparable both in antidepressant efficacy and tolerability. Doubling the low dosage in non-responders after 3 weeks resulted in a statistically significant improvement of CGI in the moclobemide group by comparison with the fluoxetine group at study end, suggesting that 600 mg moclobemide/day can still improve the patient's condition, while 40 mg fluoxetine/day does not. Sexual dysfunction was reported in two patients taking fluoxetine.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0033-3158
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
118
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
183-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7617806-Adolescent,
pubmed-meshheading:7617806-Adult,
pubmed-meshheading:7617806-Aged,
pubmed-meshheading:7617806-Antidepressive Agents,
pubmed-meshheading:7617806-Benzamides,
pubmed-meshheading:7617806-Depressive Disorder,
pubmed-meshheading:7617806-Dose-Response Relationship, Drug,
pubmed-meshheading:7617806-Double-Blind Method,
pubmed-meshheading:7617806-Drug Administration Schedule,
pubmed-meshheading:7617806-Female,
pubmed-meshheading:7617806-Fluoxetine,
pubmed-meshheading:7617806-Humans,
pubmed-meshheading:7617806-Male,
pubmed-meshheading:7617806-Middle Aged,
pubmed-meshheading:7617806-Moclobemide,
pubmed-meshheading:7617806-Sexual Dysfunctions, Psychological,
pubmed-meshheading:7617806-Time Factors
|
pubmed:year |
1995
|
pubmed:articleTitle |
Moclobemide versus fluoxetine for a major depressive episode.
|
pubmed:affiliation |
University Department of Psychiatry, Clinical University of Mont-Godinne, Mont, Yvoir, Belgium.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|