| pubmed-article:7617031 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7617031 | lifeskim:mentions | umls-concept:C0442504 | lld:lifeskim |
| pubmed-article:7617031 | lifeskim:mentions | umls-concept:C0441635 | lld:lifeskim |
| pubmed-article:7617031 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:7617031 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:7617031 | pubmed:issue | 6537 | lld:pubmed |
| pubmed-article:7617031 | pubmed:dateCreated | 1995-8-22 | lld:pubmed |
| pubmed-article:7617031 | pubmed:abstractText | Affinity maturation of antibodies is characterized by localized hypermutation of the DNA around the V segment. Here we show, using mice containing single or multiple transgene constructs, that an immunoglobulin V kappa segment can be replaced by human beta-globin or prokaryotic neo or gpt genes without affecting the rate of hypermutation; the V gene itself is not necessary for recruiting hypermutation. The ability to target hypermutation to heterologous genes in vivo could find more general applications in biology. | lld:pubmed |
| pubmed-article:7617031 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7617031 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7617031 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7617031 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7617031 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7617031 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:MilsteinCC | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:PannellRR | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:NeubergerM... | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:LozanoFF | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:ChuiY LYL | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:González... | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:KlirTT | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:YélamosJJ | lld:pubmed |
| pubmed-article:7617031 | pubmed:author | pubmed-author:GoyenecheaBB | lld:pubmed |
| pubmed-article:7617031 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7617031 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:7617031 | pubmed:volume | 376 | lld:pubmed |
| pubmed-article:7617031 | pubmed:geneSymbol | gpt | lld:pubmed |
| pubmed-article:7617031 | pubmed:geneSymbol | neo | lld:pubmed |
| pubmed-article:7617031 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7617031 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7617031 | pubmed:pagination | 225-9 | lld:pubmed |
| pubmed-article:7617031 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7617031 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7617031 | pubmed:articleTitle | Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. | lld:pubmed |
| pubmed-article:7617031 | pubmed:affiliation | Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. | lld:pubmed |
| pubmed-article:7617031 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7617031 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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