Linked Life Data

7614408

Source:http://linkedlifedata.com/resource/pubmed/id/7614408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-8-24
pubmed:abstractText
While cytokines such as interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) are partially effective in the treatment of metastatic renal cell carcinoma, these cytokines have not been investigated for their ability to suppress the development of metastasis. We investigated whether they suppressed experimental pulmonary metastasis by subline-2 of streptozotocin-induced mouse renal adenocarcinoma (MRAC-PM2). IFN-gamma (1 x 10(4) and 1 x 10(5) U/mouse) and IL-2 (1 x 10(4) and 1 x 10(5) U/mouse) suppressed the experimental pulmonary metastasis of MRAC-PM2 in a dose-dependent manner, but 1 x 10(5) IU/mouse of IFN-alpha did not. The combination of 1 x 10(5) U IFN-gamma with 1 x 10(5) U IL-2 had the most powerful inhibitory effect on pulmonary metastasis without any side-effects. In addition, the combination of 1 x 10(5) U IFN-gamma with 1 x 10(5) U IL-2 had a synergistic inhibitory effect on the growth of subcutaneous tumors. These results indicate that either IFN-gamma or IL-2, or their combination, produce a more favorable effect than IFN-alpha on the metastatic development of renal adenocarcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0919-8172
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-11
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Interferon-gamma and interleukin-2 suppress the experimental metastasis of mouse renal adenocarcinoma.
pubmed:affiliation
Department of Urology, Sapporo Medical University, School of Medicine, Japan.
pubmed:publicationType
Journal Article