Linked Life Data

7613990

Source:http://linkedlifedata.com/resource/pubmed/id/7613990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-8-23
pubmed:abstractText
Protection of 10(-4) M daunorubicin hydrochloride (DNRUB) solutions against photolytic degradation was investigated using sodium sulfite (SS). Photodegradation of the drug under fluorescent light was found to be accelerated at higher pHs, and the photoprotecting ability of SS (1.9 x 10(-3) M) increased progressively with an increase in pH in the range of 3.7 to 8.2. Increase in ionic strength (mu) appeared to decrease the rate of degradation of the drug, in the presence or absence of SS, in acetate buffer (0.1 M) of pH 5.5. Photostability of DNRUB solutions was enhanced with an increase in SS concentration in pH 6.5 citrate buffer (0.1 M, mu = 0.5). The effect of various buffer species on the photostability of DNRUB was carried out using acetate, phosphate and citrate buffers. Divalent phosphate anion appeared to demonstrate the greatest catalyzing effect followed by trivalent citrate, combination of divalent and trivalent citrate (9:11 molar ratio), and monovalent acetate anion. Sodium sulfite was found to significantly diminish the catalyzing effect of all the buffers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1079-7440
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
122-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Photoprotection of daunorubicin hydrochloride with sodium sulfite.
pubmed:affiliation
College of Pharmacy, University of Michigan, Ann Arbor, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.