Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-3
|
pubmed:dateCreated |
1995-8-24
|
pubmed:abstractText |
Serum levels of interleukin (IL)-4, interferon (IFN)-gamma and soluble CD23 (sCD23) were analysed in a prospective study of 64 infants monitored from birth to 18 months of age. The levels were low at birth and then increased, reaching a peak at either 6 or 9 months and then decreased up to 18 months of age. The children who developed atopic disease during the first 18 months of life had significantly higher IL-4 median levels than those who did not. No relationship was seen between the levels of sCD23 and IFN-gamma and allergy. Thus, the IL-4 levels in serum, but not sCD23 and IFN-gamma, were associated with allergic disease in infancy. Elevated levels were recorded before the onset of clinical symptoms, indicating that atopic disease is associated with a primary deviation of T cell function.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
1018-2438
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
107
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
34-6
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:7613164-Humans,
pubmed-meshheading:7613164-Hypersensitivity, Immediate,
pubmed-meshheading:7613164-Immunoglobulin E,
pubmed-meshheading:7613164-Incidence,
pubmed-meshheading:7613164-Infant,
pubmed-meshheading:7613164-Infant, Newborn,
pubmed-meshheading:7613164-Infant Food,
pubmed-meshheading:7613164-Interferon-gamma,
pubmed-meshheading:7613164-Interleukin-4,
pubmed-meshheading:7613164-Intradermal Tests,
pubmed-meshheading:7613164-Prospective Studies,
pubmed-meshheading:7613164-Receptors, IgE,
pubmed-meshheading:7613164-Sweden
|
pubmed:articleTitle |
Interleukin-4, soluble CD23 and interferon-gamma levels in serum during the first 18 months of life.
|
pubmed:affiliation |
Department of Paediatrics, University Hospital, Faculty of Health Sciences, Linköping University, Sweden.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|