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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
1995-8-24
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pubmed:abstractText |
Genetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x 10(-6)). These and other data suggest that IL4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the IL4 gene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7613143-Antibody Formation,
pubmed-meshheading:7613143-Antibody Specificity,
pubmed-meshheading:7613143-Chromosomes, Human, Pair 5,
pubmed-meshheading:7613143-Consanguinity,
pubmed-meshheading:7613143-Disease Susceptibility,
pubmed-meshheading:7613143-Ethnic Groups,
pubmed-meshheading:7613143-Gene Expression Regulation,
pubmed-meshheading:7613143-Genetic Linkage,
pubmed-meshheading:7613143-Genetic Markers,
pubmed-meshheading:7613143-Genetic Predisposition to Disease,
pubmed-meshheading:7613143-Humans,
pubmed-meshheading:7613143-Hypersensitivity, Immediate,
pubmed-meshheading:7613143-Immunoglobulin E,
pubmed-meshheading:7613143-Interleukin-4,
pubmed-meshheading:7613143-Th2 Cells
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pubmed:articleTitle |
Genetic basis of IgE responsiveness: relevance to the atopic diseases.
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pubmed:affiliation |
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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