Linked Life Data

7613093

Source:http://linkedlifedata.com/resource/pubmed/id/7613093

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-8-22
pubmed:abstractText
Nearly every eukaryotic mRNA contains a poly(A) tail at its 3' end. Unlike the factors that catalyze other RNA processing reactions, the basal polyadenylation machinery consists entirely of proteins. As with other steps in gene expression, however, this machinery is complex, consisting of multiple separable factors. Two multisubunit factors are required for specification of the poly(A) site and formation of a stable protein-RNA complex. Two additional proteins, as well as poly(A) polymerase, join the complex and are required for cleavage of the pre-mRNA and synthesis of the poly(A) tail, respectively. These and other properties suggest at least a superficial similarity between transcription initiation and polyadenylation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0959-437X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A complex protein assembly catalyzes polyadenylation of mRNA precursors.
pubmed:affiliation
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review