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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-8-18
|
| pubmed:abstractText |
The placental transfer of D- and L-glucose was investigated in anaesthetised non-diabetic and streptozotocin-induced diabetic rats. Maternal to fetal transfer was determined by perfusing the fetal side of one placenta in situ whilst infusing a mixture of D-[3-3H]glucose and L-[1-14C]glucose into the maternal circulation. Back-transfer from the fetal to maternal circulation was assessed by determining the uptake of the radiolabelled glucoses from the perfusion fluid during a single passage through the placenta on the fetal side. Maternal diabetes resulted in a reduced utero-placental blood flow but an increased bidirectional transfer of D-glucose. Non-specific maternal to fetal placental transfer of L-glucose was greater in diabetic rats than in controls, and the loss of L-glucose during placental perfusion on the fetal side was, again, greater in diabetic than in control rats. This increased bidirectional 'leak' of glucose possibly reflects a functionally compromised placenta, caused by its formation in a diabetic milieu, and may explain the greater fetal-maternal glucose ratios found in diabetic rats relative to controls.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0940-5429
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-7
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:7612913-Animals,
pubmed-meshheading:7612913-Blood Glucose,
pubmed-meshheading:7612913-Body Weight,
pubmed-meshheading:7612913-Carbon Radioisotopes,
pubmed-meshheading:7612913-Diabetes Mellitus, Experimental,
pubmed-meshheading:7612913-Female,
pubmed-meshheading:7612913-Fetal Blood,
pubmed-meshheading:7612913-Fetus,
pubmed-meshheading:7612913-Glucose,
pubmed-meshheading:7612913-Male,
pubmed-meshheading:7612913-Maternal-Fetal Exchange,
pubmed-meshheading:7612913-Placenta,
pubmed-meshheading:7612913-Pregnancy,
pubmed-meshheading:7612913-Pregnancy, Animal,
pubmed-meshheading:7612913-Pregnancy in Diabetics,
pubmed-meshheading:7612913-Radioisotope Dilution Technique,
pubmed-meshheading:7612913-Rats,
pubmed-meshheading:7612913-Reference Values,
pubmed-meshheading:7612913-Stereoisomerism,
pubmed-meshheading:7612913-Tritium
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Bidirectional placental transfer ('leak') of L-glucose in control and diabetic rats.
|
| pubmed:affiliation |
Division of Medicine, United Medical School of Guy's Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|