Linked Life Data

7612885

Source:http://linkedlifedata.com/resource/pubmed/id/7612885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-8-22
pubmed:abstractText
Corpora amylacea (CAm) are amorphous structures that increase in number in the brains of patients with neurodegenerative diseases. We found abundant CAm in the brains of Alzheimer disease (AD) patients. We show here that proteins of the anion exchanger (AE) gene family, related to erythrocyte band 3, are present in CAm. The presence of AE epitopes in CAm may be related to the presence of AE proteins in membranes of neurones, and their altered expression level in degenerating neurones in AD brains. Whereas the distribution of immunoreactivity was uniform over the CAm in control brains, there was much more variation in staining of CAm core and peripheral structures in AD brains. Our data support the suggestion that accumulation of altered neuronal membrane proteins may be involved in the pathogenesis of CAm in AD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
929-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Anion exchange proteins are a component of corpora amylacea in Alzheimer disease brain.
pubmed:affiliation
Research Laboratory of Neuromorphology, University of Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't