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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
|
pubmed:dateCreated |
1995-8-11
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pubmed:abstractText |
Using topical instillation of non-selective and selective beta-adrenoceptor antagonists we examine the proposal that a deficit in inhibitory sympathetic innervation of ciliary smooth muscle may be a specific precursor to the onset and development of late-onset myopia (LOM). Post-task accommodative hysteresis, a possible consequence of such a deficit, was assessed by measuring the time-course of regression of accommodation when open-loop (darkness) conditions were immediately imposed following far and near tasks. For the proposal to be feasible only LOMs should exhibit post-task responses which fail to differentiate the type of beta-antagonist employed. As the overall profile of responses to beta-adrenoceptor antagonism was equivalent for each of the three different refractive groups (emmetropes N = 6; early-onset myopes N = 5; LOMs N = 5) we conclude that a propensity to LOM is not associated with a deficit in sympathetic inhibition.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0042-6989
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1305-12
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1995
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pubmed:articleTitle |
The effect of topical beta-adrenoceptor antagonists on accommodation in emmetropia and myopia.
|
pubmed:affiliation |
Department of Vision Sciences, Aston University, Aston Triangle, Birmingham, UK.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|